Anti-HIRA (center) antibody produced in rabbit, saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution

General description

HIRA is a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this protein in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. It plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate protein in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.

Immunogen

HIRA (NP_003316, 436-471)This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human HIRA.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.